AVA is built on proof,
not hype
What does the science say?
Explore the studiesAVA's formula was clinically validated through a double-blind, randomised, placebo-controlled trial — the gold standard in scientific research. 80 participants. 12 weeks. Measurable results.
Sharper memory, sustained focus
All-day energy, no crash
Zero side effects
Across all 80 participants for the full 12-week trial. 96% compliance rate.
Sustained performance,
not a spike and crash
Peer-reviewed research
At AVA, science is at the heart of everything we formulate. Our commitment to research goes beyond marketing claims — we rely on peer-reviewed, published studies to guide every ingredient decision.
Each ingredient in AVA is supported by clinical evidence from leading scientific journals. We prioritise human trials over animal studies, and favour randomised controlled trials wherever possible.
Below is a selection of the key studies that inform our formulation. We will continue to update this page as new research becomes available.
CiticolineEffects of citicoline supplementation on cognitive function in healthy adults
This RCT found that citicoline significantly improved attention, cognitive processing speed, and working memory in healthy adults after 12 weeks of daily use.
Read full paper →CiticolineCiticoline improves memory performance in elderly subjects
A 12-week double-blind trial demonstrating that CDP-choline supplementation improved delayed recall and overall memory performance in older adults with age-associated memory impairment.
Read full paper →Lion's ManeLion's Mane mushroom and nerve growth factor: a systematic review
Comprehensive review demonstrating that Hericium erinaceus stimulates nerve growth factor synthesis, supporting neuroplasticity and cognitive function in human subjects.
Read full paper →Lion's ManeImproving effects of Yamabushitake on mild cognitive impairment
Japanese double-blind trial showing that 16 weeks of Lion's Mane supplementation significantly improved cognitive function scores compared to placebo in adults aged 50-80.
Read full paper →RhodiolaRhodiola rosea and mental fatigue: a double-blind, placebo-controlled trial
Participants receiving Rhodiola rosea showed significant reductions in mental fatigue and improvements in cognitive function during prolonged stress, with no adverse side effects.
Read full paper →RhodiolaRhodiola rosea in stress-induced fatigue: a double-blind crossover study
Crossover study demonstrating that Rhodiola extract significantly reduced cortisol response and improved performance on work-related tasks during periods of burnout and fatigue.
Read full paper →GinsengPanax ginseng and cognitive performance: a meta-analysis of RCTs
Meta-analysis of 10 RCTs showing Panax ginseng produced significant improvements in cognitive performance, reaction time, and self-reported quality of life measures.
Read full paper →GinsengModulation of cognition and mood following Panax ginseng administration
Acute dosing study showing that a single dose of Panax ginseng improved working memory, calmness ratings, and mental arithmetic speed within hours of consumption.
Read full paper →CoQ10Coenzyme Q10 and cellular energy production: implications for fatigue
Research demonstrating CoQ10's role in mitochondrial ATP synthesis and its potential to reduce both physical and mental fatigue through enhanced cellular energy metabolism.
Read full paper →CoQ10CoQ10 supplementation reduces oxidative stress in healthy adults
Clinical trial demonstrating that 12 weeks of CoQ10 supplementation significantly reduced markers of oxidative stress while increasing superoxide dismutase activity in healthy adults.
Read full paper →NRNicotinamide riboside augments NAD+ and improves bioenergetics in humans
Landmark study demonstrating that NR supplementation effectively increases NAD+ levels in humans, supporting mitochondrial function, DNA repair, and cellular energy production.
Read full paper →NRChronic NR supplementation elevates NAD+ in healthy middle-aged adults
Eight-week trial confirming NR supplementation safely and sustainably elevated NAD+ levels by an average of 60% in adults aged 55-79, with no adverse effects.
Read full paper →NACN-Acetyl Cysteine as a glutathione precursor: neuroprotective mechanisms
Review of clinical evidence supporting NAC's role in replenishing glutathione levels, reducing oxidative stress markers, and providing neuroprotective benefits in healthy adults.
Read full paper →AstaxanthinAstaxanthin supplementation and oxidative stress biomarkers in humans
Clinical trial showing that astaxanthin significantly reduced oxidative stress biomarkers and improved antioxidant capacity, with benefits for cardiovascular and cognitive health.
Read full paper →ALCARAcetyl-L-Carnitine and cognitive function: a randomised controlled trial
This RCT demonstrated that ALCAR supplementation improved cognitive processing speed, reduced mental fatigue, and enhanced mitochondrial energy output in adults aged 25-60.
Read full paper →ALCARAcetyl-L-Carnitine: from metabolic substrate to neuroprotective agent
Comprehensive review of ALCAR's dual role in mitochondrial energy metabolism and neuroprotection, with evidence from multiple human trials supporting cognitive benefits.
Read full paper →B VitaminsB vitamins and the brain: mechanisms, dose, and efficacy
Extensive review covering the essential roles of B6 (P5P) and B12 (methylcobalamin) in neurotransmitter synthesis, homocysteine metabolism, and their impact on cognitive function and mood.
Read full paper →ZincZinc supplementation and cognitive function: a systematic review of RCTs
Systematic review of RCTs confirming that zinc supplementation positively impacts attention, memory, and learning capacity, particularly in populations with suboptimal zinc status.
Read full paper →Science you can trust
Every ingredient. Every dose. Backed by research, verified by independent labs.
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